GOT7 IS OUR NAME

GOT7, Persian sub, Program ۱۳۳ comments

 

دانلود برنامه ‘GOT7 IS OUR NAME’ از چنل یوتیوب گات‌سون تا قسمت ۱۷ اضافه شد+زیرنویس تا قسمت ۱۷

episode.01 Recording Behind The Scene (1)

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episode.02 Recording Behind The Scene (2)

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episode.03 Concept Photo Behind The Scene (1)

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episode.04 Concept Photo Behind The Scene (2)

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episode.05 Concept Photo Behind The Scene (3)

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episode.06  Concept Photo Behind The Scene(4)

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 episode 07.drawing by GOT7

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 episode 08  dance practice behind the scene (1)

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 episode 09 dance practice behind the scene (2)

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 episode 10 dance practice behind the scene (3)

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episode 11 . Music video behind the scene(1)

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episode 12  Music video behind the scene(2)

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episode 13  FANCON HOMECOMING Practice

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episode 14  FANCON HOMECOMING behind The scene(1)

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episode 15  FANCON HOMECOMING behind The scene(2)

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episode 16  FANCON HOMECOMING behind The scene(3)

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episode 17  got7 press conference

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“درصورت حذف شدن لینک به اینجا مراجعه کنید”

۱۳۳ comments

  1. سلام فنکافه عزیزم??
    خیلی ممنونم که این برنامه رو ترجمه میکنید?
    فقط اینکه از قسمت ۳ به بعد دیگه کیفیت ۷۲۰ رو نمیزارید؟؟ اخه ۴۸۰ واقعا کمه… اگر امکانش هست لطفا بزارید?

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  130. Past the primary regulatory choice for apitegromab, companies are pivoting to the larger potential medical and industrial alternative for muscle mass preservation in overweight and overweight individuals taking the wildly in style incretin mimetic weight-loss medicine. There are a number of intervention factors being exploited to inhibit myostatin signaling so as to improve muscle mass under the situations of muscle atrophy. Outcomes of a quantity of Phase 2 trials underway are awaited to determine if elevated muscle volumes translate into muscle energy, efficiency and outcomes which may be clinically meaningful to sufferers. Perhaps not surprisingly skeletal muscle tumors, particularly rhabdomyosarcomas (RMS), the commonest soft tissue tumor in kids, are recognized to overexpress myostatin [92]. Blocking myostatin exercise with a dominant unfavorable type of ActRIIB resulted in decreased proliferation and promoted differentiation of a human RMS cell line suggesting that myostatin inhibition may be a priceless target for interventions for RMS [93]. Extra interestingly, Lokireddy et al.[94▪▪] for the primary time reported that myostatin protein is expressed and secreted from the mouse adenocarcinoma cell line C26, and from several human cancer cell strains.
    Computer-aided drug design is extensively regarded in the context of drug improvement [23], and the discovery of promising lead compounds utilizing these approaches offers an effective means of designing compounds with the required therapeutic profiles [24]. Peptides are short-chain amino acids with prodigious traits, such as excessive specificity and membrane penetration efficiency, and in addition, they’re fairly cheap [25,26]. For these purposes, the design of peptides that mimic specific proteins has monumental therapeutic potential. Peptides have already had main impacts on the pharmaceutical business and the instructions of organic and chemical analysis [27].
    On the other hand, serum MSTN levels are elevated in aged people and inversely correlated with lean mass. This discordance could stem from the technical limitations of enzyme-linked immunosorbent assays or radioimmunoassays used to discriminate between active and inactive MSTN or between MSTN and the similar protein (GDF-11) (Yarasheski et al., 2002). In SM, although MSTN mRNA ranges aren’t correlated with age, MSTN protein levels are elevated in elderly subjects. Moreover, MSTN protein ranges are larger in the muscle tissues of elderly males than in wholesome young males after acute muscle train (McKay et al., 2012). Sarcopenia is the result of a decline in the variety of motor models and muscle fiber atrophy and is more prevalent nowadays due to the increasing variety of aged (Stoever et al., 2017). Although it’s well known that reduced protein synthesis and/or elevated protein degradation induces SM atrophy, stories concerning the underlying molecular pathways are inconsistent. Nevertheless, numerous stories have demonstrated that MSTN is a possible therapeutic goal (White and LeBrasseur, 2014).
    Please keep in thoughts that the FDA hasn’t approved these supplements to prevent age-related muscle wasting or are assured to result in muscle progress. Still, we needed to take a better have a look at these compounds to see how they may work to assist myostatin inhibition. Like any intervention in the body’s natural processes, you want to cautiously approach these items. While natural myostatin inhibitors are usually thought of protected when used appropriately, consulting with a healthcare provider is all the time a good follow, especially when altering one thing as basic as muscle development regulation. Myocytes of the center and myoblasts (precursors of skeletal muscle cells) contain the gene — MSTN — that regulates myostatin ranges. As such, relative myostatin mRNA expression is a common biomarker in epicatechin analysis.
    Administration of this peptide to MDX mice (a mannequin of DMD) significantly elevated muscle mass. Sulfo-polysaccharide is a nutrient that is advertised to bind to myostatin and inhibit its exercise in muscle. Sulfo-polysaccharide’s active ingredient is a brown sea algae generally identified as cystoseira canariensis.
    This seaweed extract can also be noted for its anti-inflammatory properties, which may help scale back muscle soreness and velocity up recovery, permitting for extra intense and frequent training sessions. Below, we focus on a few of the most popular and effective components utilized in supplements which might be known to impact myostatin ranges or activity. So the researchers wonder if creatine, leucine and HMB can reinforce each other’s myostatin inhibitory impact. This concept turns into extra believable when you take into account the evidence that leucine and HMB in all probability stimulate muscle growth via completely different mechanisms. ResultsAs a result of the myostatin, the muscle cells produced less MyoD, however the presence of leucine, HMB and creatine corrected this.
    Ultimately, the creator emphasised that only some research endorsed the influence of non-protein dietary supplements on myostatin, and their use remains unsupported. The full cycle has been proven in research by injecting mice with myostatin, seeing them enter superior muscle wastage, after which reversing it by administering one of many myostatin inhibitors (e.g. follistatin or myostatin-propeptide). Glad you requested, as a end result of that’s one of many problems with oversimplifying this concern. Knocking out the myostatin gene at delivery or inhibiting the protein it encodes later in life seems to positively affect muscle progress, in mice at least. Apart from the fact that the athletic group views myostatin inhibition as cheating, the scientific analysis about its opposed effects for athletic enhancement is sparse.
    Follistatin, one other TGF-β superfamily member, has additionally been reported to be concerned within the regulation of muscle measurement and mass [19,20]. Drug improvement targeting MSTN or its signaling pathways is being actively pursued. The amount of nuclear FOXO1 was elevated in myotubes after MSTN therapy (McFarlane et al., 2006). FOXO1 and Smad2 have been found to synergistically enhance the MSTN mRNA expression and its promoter activity within the myotube of the C2C12 cell (Allen and Unterman, 2007). As A End Result Of SM is largely composed of proteins, an imbalance between protein synthesis and degradation sensitively impacts muscle mass, and reductions in muscle mass may result in practical disability and a rise in the threat of injury and mortality. Cachexia and sarcopenia are two consultant circumstances that are closely associated to gradual muscle loss and its inevitable penalties.
    Atrogin1, MuRF1, and ACRVIIB mRNA and protein expression have been analyzed in MIF1- and MIF2-treated cells, and ACVRIIB mRNA and protein expression have been decrease in MIF2-treated cells than in non-treated controls (Supplementary Determine S3). In addition, Smad2 and Smad3 expression had been considerably decreased in MIF2-treated cells, while Smad3 expression was decreased in MIF1-treated cells (Supplementary Determine S4). Altogether, these outcomes present that the MIF1 and MF2 peptides improve myoblast proliferation and differentiation.
    Researchers have traditionally assumed EGCG is responsible for the myriad health advantages of green tea, but latest data suggests that may not be the case [5]. The EGCG from green tea has limited bioavailability and is unstable in neutral-alkaline pH ranges [6]. Jacked Gorilla was based in 2013, and began publishing bodybuilding complement critiques, and well-known workout routines.
    MSTN inhibition is taken into account to be a potentially efficient technique of addressing the problem of muscle loss. Computational methods are broadly used to find novel inhibitors in a fast and cost-effective manner, sometimes through peptide design and compound screening. Normally, peptides are generated based mostly on the 3D constructions of protein complexes (Baig et al., 2018). Peptide fragments are sometimes created from the interacting residues of protein-protein interactions (PPIs), which are central issues in rational drug design (Baig et al., 2016). Computational screening of large compound collections towards the binding sites of target proteins usually ends in the fast identification of potential ligands. Virtual screening (VS.) is often conducted using structure- and ligand-based approaches (Baig et al., 2016).
    Follistatin is a protein that has been shown to inhibit myostatin, the protein that inhibits muscle from rising “too massive.” You’ve most likely seen photos of mice, cattle, and even a human baby with a pure myostatin defect that triggered them to develop monumental mass. Whereas the precise action of MYO-T12 just isn’t identified, it’s thought to inhibit myostatin on the gene stage. Whether Or Not you’re seeking to bulk up for a competition or just improve your physical prowess, these dietary supplements might just be the secret ingredient you need. Follidrone by Black Lion Analysis delivers a powerful formulation aimed toward lowering myostatin ranges to maximize muscle progress and optimize restoration. Anafuse by Important Alchemy combines epicatechin together with other natural anabolic extracts to promote synergistic effects in muscle progress, energy enhancement, and boosted restoration, making it suitable for those trying to obtain sustainable muscle features naturally. These cutting-edge supplements are like a secret weapon for bodybuilders and fitness enthusiasts aiming to attain peak muscle development and performance.
    The MSTN protein sequence includes a secretion sign sequence, a proteolytic processing site, and a carboxy-terminal area with a conserved sample of 9 cysteine residues, all of which are shared by TGF-superfamily members. MSTN activation requires proteolytic cleavages of the precursor protein by a furin household enzyme and BMP1/Tolloid matrix metalloproteinase (Huang et al., 2011). Natural MSTN mutations in elevated SM mass in many species together with humans and comparable outcomes have been observed in MSTN null experimental mice (Amthor et al., 2007). During embryogenesis, MSTN is produced by cells within the myotome and growing SM and regulates the overall quantity of muscle fibers fashioned. In adults, MSTN is secreted by SM, circulates in the blood, and inhibits muscle fiber growth (Lee, 2012). Myostatin (MSTN) is a well-reported unfavorable regulator of muscle development and a member of the reworking development issue (TGF) family.
    Not Like extra experimental substances corresponding to YK11, epicatechin has been studied for its potential to reinforce athletic performance and muscle health safely. In this part, we’ll spotlight a number of the top-searched myostatin inhibitor dietary supplements obtainable in the marketplace. Leonard enjoys weight coaching, playing basketball and yoga, and in addition enjoys hiking. SuperHuman Muscle by Alpha Lion is engineered to assist rapid muscle development and enhanced performance with a potent combination of performance-boosting elements. Based Mostly on current proof, a clinically efficient dose of (-)-epicatechin is 1 – ۱٫۵ mg per kg of physique weight day by day. For instance, a 100-kg individual should aim for a minimum of one hundred mg of epicatechin per day for correct results.
    Some say it actually works well, whereas others report no noticeable outcomes and even loss of weight. Buyer Evaluations, including Product Star Ratings assist prospects to be taught more about the product and determine whether or not it’s the right product for them. These symptoms could also be more prone to happen with venlafaxine or desvenlafaxine, although they can happen when any SNRI is stopped suddenly.
    These findings suggest that Ac-MIF1 and Ac-MIF2-NH2 may be useful therapeutic brokers for the therapy of muscle-related ailments. Research, including randomized clinical trials with each clinical and sports activities populations, as nicely as those with muscle-wasting situations like sarcopenia, provides combined results on myostatin inhibitors. These studies look at how food plan supplements, nutraceuticals, and exercise have an result on muscle tissues and blood myostatin. The findings show varied results—some present decreases in myostatin ranges, others show increases, and a few find no effect [1]. Dark chocolate extracts and similar flavonol-containing extracts have been studied due to their abilities to extend exercise performance. The specific flavanol, (–)-epicatechin, has been identified to extend nitric oxide production, increase mitochondrial biogenesis, improve angiogenesis, decrease myostatin, enhance follistatin, and improve train performance in rodents.
    Prospects find that the nutritional supplement helps them keep muscle energy and restoration. However, some prospects have reported points with the dosage being half what marketed, and the diet label not matching the product pictures. Customers are glad with the dietary supplement’s effectiveness and high quality elements. These initial examine results are provocative and warrant additional rigorous examination.
    A characterization of myostatin expression in main tumors is warranted in gentle of those initial findings. Cordycepin, also known as 3′-deoxyadenosine, is a key lively compound found in Cordyceps militaris9. Analysis has proven that cordycepin displays antioxidant10, anti-inflammatory11, and neuroprotective effects12. Moreover, earlier analysis has indicated that cordycepin can improve contractility of isolated skeletal muscular tissues and delay the onset of exercise fatigue in isolated skeletal muscles14. Pressured treadmill exercise is a common modeling technique to induce fatigue by forcing experimental animals to perform extreme train, as properly as, forced treadmill exercise is widely utilized in pharmacology, fatigue nutritional dietary supplements, and sports-related fields. Augmentation of protein or energy intake without concurrently addressing irritation and oxidative stress by way of the administration of anti-inflammatory brokers or antioxidants might not end in favorable outcomes.
    This intake was considered as part of their regular food regimen and was accounted for in evaluation of dietary consumption. In a post-stroke muscle loss mouse model, PINTA-745 demonstrated a big improve in muscle mass, energy, and motor perform [68]. MSTN’s relationship with muscle growth has led to the widespread examine of its inhibition for the remedy of muscle, bone, and metabolic illnesses, as properly as enhancing agricultural meat manufacturing [8–۱۱]. Scientific trials utilizing MSTN inhibitors started within the early 2000s, primarily aiming to increase muscular operate and survivability in muscular dystrophies. Despite attaining widespread success in preliminary animal trials, the journey to market for MSTN-based medication has been largely disappointing, as not certainly one of the clinically tested inhibitors have been approved for mediating muscle mass [12–۱۴]. Although the medical failures of muscular dystrophy-targeting medicine have branded MSTN inhibitors as a fruitless endeavor, latest advancements in inhibitor utility and design supply promising prospects for creating viable MSTN therapeutics.
    Cocoa extracts that contain epicatechin can help in promoting higher blood circulate and in improving the cells sensitivity to insulin. In vitro and in vivo experiments were accomplished on Leydig cells (cells responsible for producing testosterone). IGF-1 LR3 works by making muscles extra sensitive to insulin which leads to the building of muscle tissues. What separates follistatin 344 from the relaxation of the proteins is that relatively less intake can deliver long-lasting results on the body. Though follistatin 344 is a recombinant by-product of naturally occurring follistatin, the shortage of human-based medical trials nonetheless makes it an illegal substance for people to devour.

    References:

    https://www.divephotoguide.com/user/dadpolish80

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