Meet me music video

Music video, Persian sub ۱۳۵ comments

دانلود موزیک ویدیو و زیرنویس فارسی آهنگ Meet me

آهنگ Meet me به همراه سینگل ژاپنی My swagger منتشر شد. این آهنگ ساخته و نوشته ی جی بی Def Soul هستش و به اندازه ی تایتل ترک توجه ژاپنی هارو به خودش جلب کرده به حدی که براش موزیک ویدیو ساختن

برای این آهنگ موزیک ویدیو رسمی ساخته شده اما فقط در کنسرت بزرگ Arena  گات سون در ژاپن پخش شد و به طور رسمی منتشر نکردنش(احتمالا میخوان توی DVD های آلبوم ژاپنی بعدی بزارنش)

*این موزیک ویدیویی که من براتون میزارم رو فنها ساختن و ترکیبی از صحنه های برنامه ی See You In Japan و DVD های تور کنسرتهای ژاپن گات سون هستش*

ترجمه ی آهنگ هم مثل همیشه شادان عزیزم زحمتش رو کشیده.لازمه بدونید که ما مترجم ژاپنی داریم و آهنگها با اطمینان ترجمه میشه.ترجمه های انگلیسی آهنگا از گوگل ترنسلیت هستش اکثرا و ما از این روش استفاده نمیکنیم.

دانلود موزیک ویدیو Meet me

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persian sub

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۱۳۵ comments

  129. (–)-Epicatechin has been proven, by a number of research, to extend capillary and mitochondrial
    density, lower myostatin expression and improve follistatin expression in humans (12, 24).
    The results of this study revealed an inhibitory effect of (–)-epicatechin supplementation on growth of peak relative aerobic power and mitochondrial density as determined by skeletal muscle SDH protein content
    in response to cycle coaching. These observations had been observed
    despite equal increases in peak power obtained during the peak oxygen consumption test.
    The PLA group elevated relative peak VO2 by a mean of 7.4 ± ۵٫۷ ml/kg/min whereas the EPI group solely increased by a mean of two.zero ± ۴٫four
    ml/kg/min.
    In the quest for enhanced muscle development and athletic efficiency, myostatin inhibiting components are crucial.
    Myostatin is a protein recognized for limiting muscle development, and inhibiting its activity can significantly improve muscle mass and power.

    Sotatercept (ACE-011), developed by Acceleron Pharma to treat osteoporosis,
    is a fusion protein in which the extracellular area of ACVR2A is linked to a human IgG
    Fc area. Notably, biweekly subcutaneous injection of ACE-011 (10
    mg/kg) for 3 months led to vital will increase in bone quantity (93%) and bone formation rate (166%) in cynomolgus monkeys [55].

    A substantial enhance in BsALP levels and
    enchancment in BMD had been also detected in a number of myeloma sufferers who
    received 4 monthly doses of ACE-011 [57], indicating ACE-011 as a
    probably efficient remedy in bone-loss problems.

    When choosing an antidepressant, your healthcare professional considers your signs, any health
    issues you have, different medicines you are taking and what
    has worked for you up to now. But stopping antidepressant
    therapy abruptly or lacking several doses may cause
    some signs. Maintain in mind that melancholy that’s not handled is a extra concerning threat factor for suicide.
    And antidepressants may lessen suicide risk
    in the lengthy term by bettering temper for many people.
    The authors of this article will make the uncooked data supporting their conclusions obtainable,
    without any hesitation or reservation.
    To speed up and enhance the process, many of these people look to using pure and artificial peptides or proteins as they’re well-researched and supply a safer alternative to the use of steroids.
    We are inclined to envision having the same figure as our fitness idols and at some
    point surpassing their greatness. Anyone thinking about
    acquiring reprints ought to contact the
    CVMA workplace (hbroughton@cvma-acmv.org) for extra copies or
    permission to make use of this material elsewhere.

    All members were questioned on the convenience of administering the powders and
    any refusal by their pet. Each powders had been thought-about straightforward to administer by all however one particular person (treatment group).
    Within the therapy group one dog was noted to be averse to the product, whereas three
    canine inside the placebo group refused the powder.
    Fortetropin was enthusiastically ingested by most dogs
    and was widely thought-about easy to administer by their homeowners.

    It is conceivable the combination of flavonols and phytochemicals found in pure cocoa might have a different effect on skeletal muscle
    adaptation to exercise. One Other side of (–)-epicatechin supplementation worthy of extra examine is the timing and duration of supplementation. Instead of continual supplementation, it may prove useful to
    examine the utilization of (–)-epicatechin when supplemented instantly
    previous to train. Studies have shown (–)-epicatechin increases blood flow through vasodilation by the use of nitric
    oxide production (3). Lastly, the potential inhibition of aerobic diversifications in skeletal muscle as a outcome of the antioxidant properties of (–)-epicatechin have to be instantly examined.

    One participant experienced a hypoglycemic fainting episode after the final training session (placebo group), and thus did not take part in the post-training exercise testing for security causes; nonetheless,
    the participant still donated post-testing blood and muscle samples.
    One Other participant was unable to complete the post-exercise peak oxygen consumption take a look at due to gear malfunction. Additionally, only 22 of
    the original 29 participants agreed to donate blood and muscle samples, and sixteen of those individuals accomplished the entire study.
    See Figure 1 for a circulate diagram of participants and Table 1
    for participant traits for these who completed the complete study at baseline.
    YK11 contributes to a rise in Activated PKB (Protein Kinase B) levels, which considerably influences bone cell proliferation.
    Investigations have established that CKD is accompanied by mitochondrial
    impairment, a finding that can be seen within the elderly [27].
    Dynamin-related protein 1 (DRP-1) is an indicator of
    mitochondrial fission that sustains mitochondrial regular conditions.
    Microarray analysis of people with CKD, together with these present process hemodialysis, has indicated a compromised mitochondrial respiratory function and consequent oxidative damage [28].
    When C2C12 cells reached 70% confluence, development
    medium was switched to myogenic differentiation medium supplemented with MIF1, MIF2, Ac-MIF1,
    or Ac-MIF2-NH2 for 3 days. Giemsa staining was performed and fusion indices
    were decided as we beforehand described [52].
    C2C12 cells have been grown in growth medium till 70% confluent,
    and then in myogenic differentiation medium (DMEM + 2% FBS + 1% P/S) supplemented with MIF1, MIF2, Ac-MIF1 and Ac-MIF2-NH2 for three
    days to advertise myoblast differentiation. Scratch assays are
    often used to check cell migration parameters corresponding to pace, persistence, and
    polarity [31].
    An attention-grabbing discovering in a few of the analysis
    is that sure myostatin inhibitors would possibly help with muscle development, but strength and performance are possibly weakened,
    relative to size. These findings make me assume myostatin expression hasn’t essentially developed to be a unfavorable progress issue to all kinds of muscle
    hypertrophy pathways. If it had, then it might make no sense that
    resistance training inhibits myostatin. By pooling studies on the subject, that report (which can additionally be fairly latest, from
    ۲۰۱۴) tells us that more research have discovered myostatin inhibition to help with muscle function/strength improvements along with the increases in mass.
    Muscle protein synthesis is the process of constructing proteins which is ready to in the end
    make up the protein content material of muscle fibers.
    Myostatin is a pure protein active in multiple species of animal, together with us people.

    When patients have tight muscular tissues, it becomes troublesome to fully address subluxations/misalignment.three They often come again reporting, “I don’t seem to hold my adjustment.”
    Subsequently, it is important to handle muscle well being
    in sufferers. CocoaVia® makes use of the patented Cocoapro® course of
    that preserves majority of the phytonutrients in cocoa beans.
    The outcomes proved that CocoaVia® promotes many health benefits similar to improved cardiometabolic operate.
    Our favourite epicatechin complement for overall well being
    and longevity isCocoaVia®. It has the very best quantity of cocoa derived
    natural epicatechin compared to different dietary
    supplements and also incorporates many extra useful compounds from cocoa
    similar to cocoa flavanols and theobromine. That also gives
    about 80 mg of epicatechin – one of many highest concentrations
    amongst pure supplements.
    Myostatin inhibition didn’t result in any measurable enhance in Akt activation,
    which is an upstream regulator of FoxO transcription factors65,sixty six, nor did it lead to a rise in p-p70s6K/p70s6K, which indicates increased
    protein synthesis31. It is noteworthy that the expression of these proteins was measured in the
    TA, which confirmed the most strong response to myostatin inhibition. But in HS, this
    muscle is subjected to continual stretch which is hypertrophic in immobilized limbs67.
    Evaluating a shortened muscle (e.g., the gastrocnemius) would
    have been informative; nevertheless, we’ve beforehand shown related expression of atrogenes
    in each the TA and gastrocnemius after 14 days of HS.

    However, Smad2 expression was not considerably decreased by the peptide
    therapy (Supplementary Figure S7). These findings
    indicate that Ac-MIF1 or Ac-MIF2-NH2 peptides promote myogenesis
    by increasing the expression of myogenic marker genes. Regardless Of the suppression of MSTN mRNA
    expression, we didn’t observe any modifications in amino acid-stimulated myotube protein synthesis, as indicated by the incorporation of
    the tyrosyl-tRNA analogue Puromycin into newly synthesised peptides.
    Subsequently, longer duration of treatment with UA
    could additionally be required to investigate the results of sustained myostatin suppression on protein synthesis.
    Supporting this speculation, it has beforehand been demonstrated that continual UA administration upregulates the exercise
    of mitochondrial respiratory complexes I and II within the skeletal muscle of muscular dystrophic or HFD-fed mice
    [۱۷, ۱۹]. In the postprandial state, as a lot as 50%
    of the glucose that is taken up by skeletal
    muscle undergoes oxidation, demonstrating the importance of
    this mechanism in glucose homeostasis [37].

    While treating muscle losing issues has offered quite a few difficulties and demonstrated restricted success,
    inhibition of MSTN might provide a more promising method to
    handle other pathologies effectively. In Distinction To situations like muscular
    dystrophy, sarcopenia, and most cancers cachexia,
    obesity and diabetes correlate with elevated serum ranges of MSTN [113].
    A examine surveying MSTN serum focus in human adults found a
    constructive correlation between weight problems and increased
    MSTN, a positive affiliation with insulin resistance, and a negative correlation with insulin sensitivity [114].
    This cause-and-effect relationship with insulin resistance is
    supported by the observed improve in insulin resistance after
    injection of MSTN in mice [115]. Furthermore, in high-fat diet-induced obesity-susceptible C57BL/6
    mice, consumption of high-fat feed led to a rise in MSTN expression,
    indicating that MSTN could play a vital function in mediating weight problems [116].

    Moreover, each sort 1 and type 2 diabetes patients were proven to have higher serum MSTN concentrations
    when in comparability with wholesome counterparts
    [۱۱۷, ۱۱۸]. The increased MSTN levels in obesity, insulin resistance, and diabetes counsel that MSTN-targeted inhibitors can enhance
    metabolic function and promote weight loss in overweight individuals.

    Additionally, in a phase 2 trial carried out with boys affected by
    DMD, vital enhancements have been noticed in muscle mass, with the group treated with 1 mg/kg each 2 weeks experiencing an approximate mean increase
    of 4–۵%. Moreover, enhancements had been famous in 6-min walk
    distance (6MWD), bone mineral density, and reductions in fat mass [12, 63].

    Nonetheless, non-muscle-related antagonistic unwanted effects
    together with nosebleeds, gum bleeding, telangiectasia, and erythema led to the discontinuation of further examine [12].
    Myostatin, a potent unfavorable regulator of skeletal muscle mass, has garnered
    important attention as a therapeutic target for muscle dystrophies.
    Despite in depth analysis and promising preclinical
    outcomes, scientific trials focusing on myostatin inhibition in muscle dystrophies have didn’t yield substantial enhancements in muscle function or fitness in patients.

    Whereas the health advantages of epicatechin and other antioxidants found in tea leaves, espresso beans,
    and cocoa beans are innumerable, the ergogenic effects of isolated epicatechin stay somewhat equivocal [1].
    Current evidence additionally raises doubts about using myostatin blockers for constructing muscle mass and preventing muscle atrophy in humans [2].
    It seems to me that if the muscle weak point is a operate of muscle mass wastage
    then there’s a correlation between myostatin inhibition and enhancements in muscle power, largely because of
    the rehabilitation of muscle tissue. Research investigating the consequences of myostatin inhibition have proven that there’s most probably a resultant enhance in muscle mass, and possibly by way of multiple
    biological pathways. In old mice, daily injections of epicatechin led to elevated
    overall muscle power. The same remedy in 6 human subjects elevated
    their hand grip strength after simply 7 days. Added to resistance coaching,
    creatine can improve the expansion potential of muscular tissues by lowering myostatin.
    Subjects had been asked to keep up their normal diet throughout the study and
    were not allowed to ingest any dietary complement that contained doubtlessly ergogenic nutrients.
    Nonetheless, topics had been permitted to ingest energy-based sports drinks, energy bars,
    and protein powders provided that they didn’t comprise any ergogenic nutrients.
    The purpose for this was that many resistance-trained athletes ingest these energy-based
    dietary supplements as a way to maintain their
    beneficial dietary consumption of calories.
    Ecdysterones have additionally been lately purported to
    boost coaching adaptations throughout resistance coaching. In help of this rivalry, research in animal fashions
    has advised that ecdysterone supplementation can promote anabolic activity in skeletal muscle [5], as well as improve cell proliferation and progress,
    which may lead to a rise in muscle mass [6]. Oral administration of
    Leuza (herbal ecdysterone) in male albino mice triggered a statistically important enhance within the time of working [19].
    After 20 days of supplementation, there was a big enhance in work capacity.

    The identical researchers evaluated the results
    of 20-day administration of ectisten-containing tincture of
    leuzea and leveton on humoral immunity of track and area
    runners for distances of 5,000 and 10,000 m.
    Additional research is required to completely elucidate
    the interactions between MSTN inhibition and metabolic problems.
    Fatigue has turn out to be more and more frequent and important with societal progress and faster tempo of life.

    Fatigue is a fancy physiological and biochemical
    process that happens when brain or physical power reaches a sure stage1.

    Skeletal muscle is a receptor tissue for androgens that positively influence muscle resilience, hypertrophy, and regeneration [91].
    Testosterone enhances muscular anabolism, accelerates protein era, prevents muscle breakdown, and boosts the effectiveness of amino acid
    reutilization in muscular tissues [92]. Over 60% of individuals with
    severe CKD exhibit decreased blood concentrations
    of testosterone, which can trigger muscle atrophy by modifying IGF-1 signaling and elevating myostatin quantities
    [۹۲]. Moreover, feminine people with CKD have estrogen scarcity in the first part of the situation, and diminished estrogen concentrations correlate
    with decreased muscular energy and functionality [81].
    In a murine mannequin of CKD, parathyroid hormone and its receptor signaling in fat tissue induce dysregulated thermogenesis and hypermetabolism, resulting in muscle loss
    [۸۶]. Consequently, human ranges of hormones even have a job
    in muscle atrophy among folks with CKD. In addition to antagonizing the myostatin ligand, concentrating
    on its receptors to dam the signaling transduction pathway has also
    been extensively explored as a treatment strategy for muscle-loss
    issues.
    Hence how some myostatin inhibor supplements are
    receiving poor reviews online with customers complaining that they
    didn’t discover a thing. Now, to become probably the greatest bodybuilders on the planet like Flex, you’ve
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    In my opinion, the collection of blood samples
    only on days 14 and 28 should be clearly stated as a limitation of the
    manuscript. Standardize the writing of the names of examine phases all through the manuscript – sometimes capitals are used as
    a first letter of the name of the phases, and within the different components
    of the manuscript lowercase is used.
    C2C12 cells (Korean Cell Line Bank, Seoul, Korea) were grown in development
    medium (DMEM (HyClone Laboratories, South Logan, UT,
    USA) + 10% FBS + 1% P/S) at 37 °C in a 5% CO2 environment.
    Peptides are gaining popularity because of their excessive
    specificity and biological actions, and since they are comparatively inexpensive, which is necessary as small-molecule medicine are expensive,
    regularly produce toxic metabolites, and
    have undesirable side effects. The use of peptides as drugs has progressed significantly and continues to evolve as drugs and therapy paradigms change.

    Since the appearance of insulin over a century ago,
    peptide therapies have played an necessary role in medical follow.
    Present peptide therapies target a extensive range of situations and are administered intravenously, subcutaneously, by
    way of inhalation, and even orally (e.g., linaclotide).

    Several peptides comprised of short sequences and modifications
    of those sequences were generated using these residues.
    As discussed above, during the activations of various signaling
    processes, and thus, the activations of atrophic
    genes, MSTN interacts with a large number of totally different proteins, which supplies clues for the
    design of peptide inhibitors of MSTN. MSCs divide
    symmetrically to increase their quantity, or asymmetrically to provide
    cohorts of committed satellite cells and consequently progenitors after they
    have been activated. Myogenic progenitors multiply and eventually differentiate by fusing with
    other myogenic progenitors or injured fibers to have the ability to
    restore fiber integrity and performance (Dumont et al., 2015; Dueweke
    et al., 2017). SM is composed of muscle fiber with a novel construction, which mainly consists of actin and myosin filaments that
    permit muscle tissue to contract and chill out. Each muscle fiber represents a muscle cell, which has a
    elementary mobile unit often recognized as the sarcomere.
    Fascicules are fashioned by bundles of myofibers, and muscle tissue is fashioned by bundles of fascicles, with
    each layer being contained by the ECM and maintained by cytoskeletal networks (Lieber and Friden, 2000).

    References:

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